Neurology

In generalized myasthenia gravis (gMG), pathogenic antibodies activate the terminal complement cascade at the neuromuscular junction, leading to membrane attack complex–mediated damage of the postsynaptic membrane. Complement C5 inhibition directly blocks this mechanism, addressing a central driver of disease rather...

The neonatal Fc receptor (FcRn) preserves IgG by preventing lysosomal degradation, thereby extending IgG half-life. Inhibition of FcRn enhances the clearance of pathogenic IgG autoantibodies, resulting in rapid and reversible reductions in circulating AChR and MuSK antibodies without causing broad...

Release Date: December 23, 2025 Expiration Date: December 23, 2026 Activity Overview The neonatal Fc receptor (FcRn) rescues immunoglobulin G (IgG) from lysosomal degradation, prolonging IgG half-life. FcRn blockade accelerates degradation of pathogenic IgG autoantibodies, leading to rapid, reversible reductions in circulating...

Activity Overview This online, on-demand virtual symposium brings together experts in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), an increasingly recognized inflammatory demyelinating disorder with distinct clinical, radiographic, and immunologic features. In this educational program, these experts share data and expert...

Activity Overview Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare, immune-mediated disorder of the peripheral nerves and nerve roots. Advances in our understanding of CIDP pathophysiology, including the role of pathogenic IgG autoantibodies, have expanded the therapeutic landscape with targeted...

Neuromuscular disorders can have a profound impact on individuals and their loved ones, but many people are unaware of the challenges faced by those affected. Moreover, there are numerous opportunities to improve care for these patients. This activity offers the...